Preheat the oven to 400°F and line a large baking sheet with parchment paper to prevent sticking and ensure even browning.

In a mixing bowl, stir together the breadcrumbs, milk, and egg until the breadcrumbs are evenly moistened. Add in the minced garlic, chili powder, onion powder, dried oregano, salt, black pepper, and red pepper flakes. Mix until well combined to form a seasoned paste.

Add the ground beef to the bowl and, using clean hands or a sturdy spoon, mix thoroughly until the seasoning mixture is evenly incorporated throughout the meat. Avoid overmixing to keep the meatballs tender.

Shape the mixture into meatballs approximately 1½ inches in diameter, and arrange them on the prepared baking sheet with a bit of space between each for proper roasting.

Bake for 20 minutes, or until the meatballs are fully cooked and have developed a deep, golden crust on the outside. An internal temperature of 160°F ensures doneness.

Once baked, remove the meatballs from the oven and allow them to rest for 5 minutes to redistribute juices. Serve hot, nestled in your favorite tomato sauce or alongside pasta, rice, or a crisp green salad for a fiery, satisfying meal.